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A microbiological paper published on the 28th by Nature magazine said that American scientists have discovered a new type of antibiotic that can kill methicillin-resistant Staphylococcus aureus, MRSA, in a mouse model. Superbug MRSA is resistant to traditional antibiotics, and this study is expected to promote the development of effective and clinically applicable new antibiotics.
Antibiotic resistance poses a growing threat to global public health, but only a very small amount of new antibiotics have been developed over the past 30 years, and new antibiotics are needed to fight multidrug-resistant pathogens. The superbug MRSA, which attracts people’s special attention, is a potentially lethal bacteria that is very difficult to treat not only because many MRSA strains are now resistant to traditional antibiotics, but also because they form metabolically inactive resistance. The antibiotics hold a subpopulation of persister cells.
This time, Eleftherios Malonencis, a scientist at Brown University in the US, and colleagues identified two synthetic retinoids that can kill the growing MRSA cells and MRSA-exposed bacteria in the experiment. One of them can effectively treat chronic MRSA mouse models.
The researchers said that the above compounds are analogs of vitamin A and have low toxicity, and they work by destroying the bacterial membrane. They work synergistically with common gentamicin, and the team believes that bacteria are unlikely to be resistant to them.
At present, researchers have described more than 4,000 natural and synthetic retinoids, which are likely to find more antibiotic candidates. At the same time, the two compounds need to be further developed to increase their safety and bring them closer to clinical trials.
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