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The Clinicla Significance Of Blood Culture
Dec 23, 2017

What is bacteremia? What is the clinical significance of blood culture?

The immune system is an important system for the human body to carry out immune response and immune function. It is the most effective weapon for defending the invasion of pathogens. It can detect and remove foreign bodies and foreign pathogenic microorganisms. When the microorganisms invade the blood and rapidly multiply beyond the ability of the immune system to clear, Symptoms or fungal sepsis.

Bacteremia is one of the common clinical critically ill, case fatality rate as high as 20% -50%. Detection of microorganisms in the patient's blood has important clinical implications for the diagnosis, treatment and prognosis of infectious diseases.

Blood culture is the most important means of diagnosis of bacteremia, isolated from the blood of bacteria may be the cause of sepsis, which provides an important basis for the diagnosis of the cause, and can further provide the basis for the correct treatment of antibiotics; blood culture positive also indicates The body limits the spread of infection or the failure of a given site's action or localized infection.

Blood culture related projects: bacteremia, fungal blood culture, mycobacterial culture, catheter-related bloodstream infections, infective endocarditis.

What symptoms do blood culture?

Fever (> 38 ° C), hypothermia (<36 ° C), leukocytosis (> 10.000 / μl) neutropenia (<1.000 / μl), hypotension, topical infections: pneumonia, urinary tract infections, meningitis , Stroke apathetic children or the elderly, frailty, delirium, sudden loss of weight in the elderly, renal insufficiency, unexplained leukocytosis and altered mental status, immunocompromised patients, CRP, PCT.

Influencing factors:

At present, the positive rate of blood culture is relatively low. According to the statistics of related data, the positive rate of blood culture in our country is about 10% -18%, and the positive rate is related to many factors

1, skin preparation and pollution prevention (disinfection, blood culture acceptable contamination rate ≤ 3%)

2, the timing of specimen collection (bacteria into the blood flow time is 1 hour before shivering and fever)

3, blood collection (adult 20-30ml, for infants and young children, blood volume does not exceed 1% of the total blood volume, increased blood volume will increase the positive rate)

4, distribution in aerobic and anaerobic bottles (a blood culture should include an aerobic and an anaerobic bottle)

5, specimen transport (collection should be immediately sent to the laboratory, after inoculation of blood culture bottles shall not be frozen or frozen, any delay into automatic continuous monitoring of blood culture instrument behavior will delay or prevent the detection of bacterial growth)